Drug-Induced Liver Injury

Key team members: Prof Guruprasad Aithal, Dr Jane Grove, Dr Andrew Bennett and Dr Nick Hannan

Considering the fact that animal toxicological investigations have singularly failed to elucidate mechanisms underlying idiosyncratic DILI, we have developed well characterised cohorts of cases of DILI and controls to investigate genetic, epigenetics and environmental factors that influence the development of this rare, yet serious adverse reactions to medications and to evaluate markers that assist in the detection, diagnosis of DILI and prevent its serious consequences. Samples from a large cohort of DILI patients is being collected through the Pro-Euro-DILI Registry award for further analysis of this disease.

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guruprasad-aithal Professor Guruprasad Aithal Biography Professor Guruprasad P. Aithal graduated with MBBS from Kasturba Medical College, Manipal, MD (Internal Medicine) from Bangalore Medical College, Bengaluru, India and completed his specialist training in Gastroenterology in the Northern…