Lower GI

Our work is focused on intestinal inflammation caused by interaction of the gut with microbes. This includes both acute gastroenteritis especially Campylobacter jejuni as well as Clostridium difficile whose overgrowth caused by antibiotic use is such an important cause of morbidity and mortality in hospitalised patients. We are also studying diseases characterised by inflammation due to breaches in the gut barrier leading to interaction of gut microbiota and host immune system. These include acute diverticulitis and inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.

Title
Campylobacter
Clostridium difficile
Diverticular Disease
Functional Bowel Disorder
Constipation
Irritable Bowel Syndrome (IBS)
Inflammatory Bowel Disease (IBD)

Title	Amount
A new MRI based disease measure in Ulcerative Colitis – Optimisation studies in Healthy Volunteers	£4,500
Effect of kiwifruit on Gastrointestinal Fluid Distribution and tansit in Healthy volunteers	£249,566
Antimicrobial peptide human deensin-5 and agent for tackling AMR and Crohns disease	£15,653
Understanding the role of microbial metabolites in the initiation and progression of Crohn’s disease	£18,417
Towards Personalised Therapies for Crohn’s Disease Using Primary Intestinal Enteroids	£99,051
A new MR-based Perianal Crohn’s disease activity score: A multi-centre study. The MAP study	£77,439
Small bowel motility quantified by cine MRI as a predictor of long term response in patients with Cr	£932,139
Proof of Concept: Assessment of a Polymer-based Nanoparticulate System to Enhance Drug Delivery of L	£14,808
A Microarray Assay for Patient Stratification and Management of C. difficile Infection	£24,000
Assessment of gut transit in paediatric constipation without ionizing radiation: Magnetic Resonance	£356,796
Altered Appetite in Crohn’s disease: Deconstructing the enteroendocrine axis using fMRI.	£140,508.32
Prophylaxis of Clostridium difficile infections	£176,237.38
Royal Society Wolfson merit award	£25,000.00
Asseel Khalaf PGR studentship	£100,000
Developing methods for measuring gut permeability and fat infiltration with MRI	£84,258
Gut Motility in Crohn’s disease. PhD Studentship	£100,000
IBD Educational Grant	£8,400
Pilot study to characterise the skeletal muscle metabolic response to a meal in patients with Crohn’	£4,500
Phenotypic assessment of C. difficile mutants in a human in vitro model of C. difficile infection	£4,500
Assessment of the in vivo effects of a glycosylated dendrimer, PETIM-DG, in a murine model of C. dif	£7,000
CLOSPORE: Understanding the Clostridium Spore, a Prerequiste for Disease Interventions and Exploita	£2,865,288.79
A Prospective Study on a Relationship Between Hydr	£61,843
Katie Elisabeth Rollins ESPEN Research Fellowship	£40,408
Confidence in Concept 2013	£85,612
MRI Study	£97,000
Effect of Gluten content of bread	£9,492
Helicobacter Eradication vs Aspirin Toxicity	£1,819,174
The effect of extreme Trendelenburg positioning	£39,222.45
European Association for Endoscopic Surgery and other interventional techniques	£36,633.22
Towards the treatment of C Diff	£109,400.00
Faecal Incontinence: Is there evidence for Synergy	£50,000
ALL-HEART Allopurinol and cardiovascular outcome	£274,121
Variety of Beverages Increase Fluid Consumption	£12,000
L171 Vaper	£18,083
11GA001 Controlled Trial of “Follow On” Rifaximin	£111,568.00
Mr Krishna Kumar Varadhan-ESPEN Fellowship	£23,939
The aetiology of pain in chronic pancreatitis	£9,825
Clostridium research project	£180,000.00
FAST (PROBE)	£335,563
Nilanjana tewari CORE fellowship	£179,665
Establishment of a resource for Long-Term study of hepatitis C Virus infection in the UK - HCV Resea	£1,920,000
Study to assess safety of GSK1605786A	£4,401
Subjects with moderately to severely active crohns	£3,126
FSF Award Gastrointestinal response to stress in IBS	£150,000
Standard Care Versus Celecoxib Outcome study	£285,599
Saccharomyces Cerevisiae Strain CNMC I-3856	£113,488
Health Technology Assessment – FIAT - fistula in ano trial	£1,200,000
Chandan Verma Clinical Research Fellowship	£264,803

Title
Effect of antibiotic treatment on the formation of non-spore Clostridium difficile persister-like ce
Surgical Rates for Crohn’s Disease are Decreasing: A Population-Based Time Trend Analysis and Valida
Living with Crohn’s disease: an exploratory cross-sectional qualitative study into decision-making a
Literature review: impacts of socioeconomic status on the risk of inflammatory bowel disease and its
MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans
Do diverticula provide a unique niche for microbiota which can lead to activation of the innate immu
High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium diffici
Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and ar
The Pattern of Underlying Cause of Death in Patients with Inflammatory Bowel Disease in England: A R
Development of Clostridium difficile R20291 Delta PaLoc model strains and in vitro methodologies re
Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with mod
New therapeutic options for IBS: the role of the first in class mixed micro- opioid receptor agonist
Development of Clostridium difficile R20291DeltaPaLoc model strains and in vitro methodologies revea
Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challen
Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and ar
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Sy
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Sy
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection
Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infectio
Diverticular Disease and IBS: Overlapping or Misunderstanding?
Diverticular Disease and IBS Overlapping or Misunderstanding?
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-re
Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain’s Response to Fat
Pan-Colonic Pressurizations Associated With Relaxation of the Anal Sphincter in Health and Disease:
Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a m
IBS and IBD - separate entities or on a spectrum?
Ustekinumab: a novel therapeutic option in Crohn’s disease
Bowel Disorders
Clostridium difficile flagella predominantly activate TLR5-linked NF-kappa B pathway in epithelial c
Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI
Colonic diverticular disease: medical treatments for acute diverticulitis
Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen intera
Magnetic Resonance Imaging Methods for the Study of Gastrointestinal Transit
Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans
Ustekinumab for the treatment of Crohn’s disease: can it find its niche?
Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previous
Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study fro
A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the
Magnetic resonance imaging to evaluate gastrointestinal function
Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI
Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution
Effect of experimental stress on the small bowel and colon in healthy humans
Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro
Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota. Neurogastroe
Risk of Acute Appendicitis in and Around Pregnancy A Population-based Cohort Study From England
The role of flagella in Clostridium difficile pathogenicity.
The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovan
SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marro
Aerated drinks increase gastric volume and reduce appetite as assessed by MRI: a randomized, balance
Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recogniz
Surgeons’ Experiences of Teaching Medical Students in the Operating Theatre: A Pan-Specialty Regiona
I’d Rather Take The Stairs - CPEX Testing, Do We Really Need It?
The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy
Should chloride-rich crystalloids remain the mainstay of fluid resuscitation to prevent ‘pre-renal’
Pre-Operative nutrition In Neck of femur Trial (POINT) - carbohydrate loading in patients with fragi
Enhanced recovery after elective colorectal surgery: Reply
Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome? Report of a case
Effects of bowel cleansing on the intestinal microbiota
Choice of fluid in acute illness: what should be given? An international consensus
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfec
Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum-evidence f
Review article: the economic impact of the irritable bowel syndrome
Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibro
Impact of postoperative non-steroidal anti-inflammatory drugs on adverse events after gastrointestin
Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: compariso
The influence of laparoscopy on incisional hernia rates: a retrospective analysis of 1057 colorectal
The feasibility and clinical efficacy of intravenous iron administration for preoperative anaemia in
Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water
The Incidence of Other Gastroenterological Disease following Diagnosis of Irritable Bowel Syndrome i
Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery (ERAS(
Nuclear Expression of Phosphorylated Focal Adhesion Kinase Is Associated with Poor Prognosis in Huma
A randomised trial of ondansetron for the treatmentof irritable bowel syndrome with diarrhoea
Comparison of culture based methods for the isolation of Clostridium difficile from stool samples in
Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroente
Dual effects of alpha(2)-adrenoceptors in modulating myogenic tone in sheep isolated internal anal s
Dual registration of abdominal motion for motility assessment in free-breathing data sets acquired u
A synthetic biology approach towards improved cellulolytic activity of Clostridium acetobutylicum AT
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predomi
Lipoprotein CD0873 Is a Novel Adhesin of Clostridium difficile
A study of the methodological and clinical validity of the combined lactulose hydrogen breath test w
Safety of Short, In-Hospital Delays Before Surgery for Acute Appendicitis
The Flagellin FliC of Clostridium difficile Is Responsible for Pleiotropic Gene Regulation during In
Incidence and Prevalence of Celiac Disease and Dermatitis Herpetiformis in the UK Over Two Decades:
Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based
Toward more accurate measurements of anorectal motor and sensory function in routine clinical practi
Characterisation of a high resolution small field of view portable gamma camera
Perioperative prebiotics, probiotics or synbiotics for elective abdominal surgery in adults - a syst
A randomized, controlled, double-blind crossover study on the effects of 1-L infusions of 6% hydroxy
Mandard Tumour Regression Grade, Perineural Invasion, Circumferential Resection Margin and Post-chem
Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movemen
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumor
Sex differences in the composition of weight gain and loss in overweight and obese adults
Novel concepts in inflammatory bowel disease
The pathophysiology of fluid and electrolyte balance in the older adult surgical patient
Irritable bowel syndrome, inflammatory bowel disease and the microbiome
Gastro 2013 APDW/WCOG Shanghai Working Party Report: Chronic diarrhea: Definition, classification, d
Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel
Overlap between Irritable Bowel Syndrome and Inflammatory Bowel Disease
Identification of Patients with Non-D, Non-C Irritable Bowel Syndrome and Treatment with Renzapride:
Serotonergic agents and the irritable bowel syndrome: what goes wrong?

Photo	Name	Bio
	Professor Robin Spiller	Professor Spiller is Professor of Gastroenterology in the NIHR Nottingham Biomedical Research Centre at the University of Nottingham. Past Editor of Gut (2003-2009) and member of the Board of the Rome Foundation (2000-2015), he twice edited the…
	Professor Christopher Hawkey	Christopher Hawkey is Professor of Gastroenterology at the Nottingham Digestive Diseases Centre. His main interests are in the field of non-steroid anti-inflammatory drugs and inflammatory bowel disease. In both areas his approach is to try to identify…
	Professor Nigel Minton	Nigel is a relative newcomer to academia. He established the Clostridia Research Group (CRG) in 2004, following 25 years of service in the applied environment of the Centre for Applied Microbiology and Research (CAMR), Porton Down. At CAMR he fulfilled a…
	Professor Yash Mahida
	Dr Maura Corsetti	Dr Maura Corsetti is a Clinical Associate Professor in Gastroenterology at the University of Nottingham. She obtained her Specialization (2000) and PhD (2004) at the "Universita' degli Studi di Milano", Italy. During her PhD she worked for two years…
	Dr Luca Marciani	I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships…
	Dr Gordon Moran	Dr Moran did his undergraduate medical training at University of Malta Medical School and was awarded an MD in 1999. He completed his basic postgraduate training at St. Luke's Hospital in Malta and gained membership of the Royal College of Physicians of…
	Dr Tanya Monaghan	Dr Monaghan came to Nottingham in 2006 and took up the position as the first NIHR Academic Clinical Fellow in Gastroenterology. Alongside clinical training, she worked in the laboratory of Professor Yash Mahida. She was subsequently awarded a Wellcome…
	Dr David Gunn
	Gita Thapaliya
	Dr Victoria Wilkinson-Smith
	Helen Foreman
	Jill Garratt
	Shellie Radford

About the Nottingham Digestive Diseases Biomedical Research Centre

For Industry