Professor Robin Spiller

Professor Robin Spiller

Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH

+44 115 823 1090 View full bio
Professor of Gastroenterology

Professor Spiller is Professor of Gastroenterology in the NIHR Nottingham Biomedical Research Centre at the University of Nottingham.

Past Editor of Gut (2003-2009) and member of the Board of the Rome Foundation (2000-2015), he twice edited the British Society of Gastroenterology (BSG) Guidelines for the management of IBS. His main research interest is the pathophysiology of irritable bowel syndrome (IBS), particularly the role of infection, inflammation, diet and alterations in the microbiome as well as a long standing collaboration with the Sir Peter Mansfield Imaging Centre pioneering the use of MRI to image the underlying mechanisms in functional bowel diseases. Author/co-author of more than 362 scientific reviews and original publications. Current funding includes £2.2M EME grant for a multicentre trial of ondansetron in IBS with diarrhoea, £1.6M MRC grant studying colonic motility using MRI and High resolution manometry and £800K Newton grant examining the effect of fibre of intestinal physiology in IBS. Our group has also performed many investigator initiated research projects with industry including Norgine, Dr Falk, Ironwood and most recently Zespri.

Studies
Title Start Date Status
Optimisation of MRI for use with PEG Electrolyte Challenge Drink for stimulating and observing colon 1st March 2015 Active
Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota (Movipr 1st March 2012 Ended
Mode of action of Moviprep: Impact on distribution of intestinal fluid and colonic microbiota 1st March 2012 Ended
Imaging the effect of experimental stress on small and large bowel water during fructose absorption 1st October 2012 Ended
A randomised placebo controlled trial of “follow on” Rifaximin for the prevention of relapse of Clos 1st November 2012 In Recruitment
MRI study of diverticular disease symptoms and its relationship to visceral adipose tissue (DOO Stud 1st January 2011 Ended
Optimising measurement of small and large bowel transit during MRI scanning and characterising IBS s 1st October 2011 Ended
An Observational Study of the Role of Antibiotics, Inflammation and Changes in Microbiota in the dev 1st November 2013 In Recruitment
Optimising measurement of small and large bowel transit during MRI scanning and characterising IBS s 1st October 2011 Ended
Validation of Magnetic Resonance Imaging to characterise gastrointestinal physiology, gut luminal co 1st April 2014 Ended
A double blind randomised placebo controlled phase III trial in patients with chronic idiopathic con 1st September 2013 Ended
Effect of physical form of apples on gastrointestinal function and satiety: a MRI study (APPLE Study 1st February 2016 In Recruitment
Effects of Fibre on Intestinal Volume and Gas in Irritable Bowel Syndrome (EFIGI) 1st March 2018 In Recruitment
Fructose, Fructants and Irritable Bowel Syndrome: MRI study of underlying mechanisms (FABS) 1st January 2013 Ended
Poorly absorbed carbohydrates (PAC): A case control study between Irritable Bowel Syndrome patients 1st October 2015 Active
A pilot randomised controlled trial of the effect of a diet low in poorly digested carbohydrates on 1st December 2015 In Recruitment
Reclassifying Constipation Using Magnetic Resonance Imaging Combined With High Resolution Manometry: 1st December 2016 In Recruitment
A randomised controlled trial of the effect of the low FODMAP diet and dietary oligofructose on gast 1st September 2014 Ended
A pilot double blind, randomised, placebo controlled trial of the effect of a diet low in poorly dig 1st August 2014 Ended
Pilot study: MRI study of Diverticular disease symptoms and its relationship to visceral adipose tis 1st April 2010 Ended
Publications
Title
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered ser
Postinfectious Irritable Bowel Syndrome
Should we treat uncomplicated symptomatic diverticular disease with fibre?
Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel
Magnetic resonance imaging to evaluate gastrointestinal function
Diverticular Disease and IBS Overlapping or Misunderstanding?
Do diverticula provide a unique niche for microbiota which can lead to activation of the innate immu
Serotonergic agents and the irritable bowel syndrome: what goes wrong?
Overlap between Irritable Bowel Syndrome and Inflammatory Bowel Disease
The shifting interface between IBS and IBD
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota. Neurogastroe
Do diverticula provide a unique niche for microbiota which can lead to activation of the innate immu
Irritable bowel syndrome - the new inflammatory bowel disease?
Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious
Potential Biomarkers
New Thoughts on the Association Between Diverticulosis and Irritable Bowel Syndrome
Gastro 2013 APDW/WCOG Shanghai Working Party Report: Chronic diarrhea: Definition, classification, d
Constipation and the Microbiome: Lumen Versus Mucosa!
Anticipation of thermal pain in diverticular disease
Identification of Patients with Non-D, Non-C Irritable Bowel Syndrome and Treatment with Renzapride:
Postinfectious Functional Dyspepsia and Postinfectious Irritable Bowel Syndrome: Different Symptoms
Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome
Gastro 2013 APDW/WCOG Shanghai Working Party Report: Chronic diarrhea: Definition, classification, d
Colonic diverticular disease: medical treatments for acute diverticulitis
Role of microbiota in the pathogenesis of functional disorders of the lower GI tract: Work in progre
Investigation of alginate beads for gastro-intestinal functionality, Part 2: In vivo characterisatio
New Insights Into Bloating and Abdominal Distension: Is It All Outlet Obstruction?
Irritable Bowel Syndrome: Gender, Infection, Lifestyle or What Else?
Quantification of Gastrointestinal Liquid Volumes and DistributionFollowing a 240 mL Dose of Water i
Diverticular Disease and IBS: Overlapping or Misunderstanding?
Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter
A Population-Based Study of Perforated Diverticular Disease Incidence and Associated Mortality
The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and con
Possible Role of Serotonin Transporter in Irritable Bowel Syndrome: Evidence From Platelet Investiga
Magnetic resonance imaging to evaluate gastrointestinal function
Psychological and colonic factors in painful diverticulosis
Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship
Bowel Disorders
Intestinal barrier function in health and gastrointestinal disease
Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered ser
Infection, inflammation, and the irritable bowel syndrome
Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case
Intestinal barrier function in health and gastrointestinal disease
Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challen
Constipation and the Microbiome: Lumen Versus Mucosa!
Bowel Disorders
Irritable bowel syndrome, inflammatory bowel disease and the microbiome
Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infectio
Irritable bowel syndrome, inflammatory bowel disease and the microbiome
Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection
A randomised trial of ondansetron for the treatmentof irritable bowel syndrome with diarrhoea
IBS and IBD - separate entities or on a spectrum?
Exploring Gastrointestinal Variables Affecting Drug and Formulation Behavior: Methodologies, Challen
Magnetic resonance spectroscopy measurements ofintragastric fat fraction of oil emulsions in humans
Assessment of motion of colonic contents in the human colon using MRI tagging
A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo (13)C ma
Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI
Magnetic Resonance Imaging Methods for the Study of Gastrointestinal Transit
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-re
MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Sy
Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in health
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Sy