Professor Nigel Minton

Professor Nigel Minton

Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD

+44 115 84 67458 View full bio
Professor of Applied Molecular Microbiology

Nigel is a relative newcomer to academia. He established the Clostridia Research Group (CRG) in 2004, following 25 years of service in the applied environment of the Centre for Applied Microbiology and Research (CAMR), Porton Down. At CAMR he fulfilled a number of different roles, including Head of the Department of Molecular Microbiology as well as Scientific Leader for Molecular Microbiology for the establishment. To date he has filed 15 patents, secured £15.7M in funding since arriving at Nottingham, leads one of the six programmes that together comprise the BBSRC Sustainable Bioenergy Centre (BSBEC) and is the PI of a recently awarded BBSRC sLoLa in Synthetic Biology. He belongs to the TMO Renewables Ltd Centre of Excellence in Biorefining, is on the LanzaTech Scientific Advisory Board, consults for Pfizer, MERCK and Ipsen Pharmaceuticals and is the scientific lead on Clostridium difficile research within Nottingham’s NIHR Biomedical Research Unit on Gastrointestinal disease.

Publications
Title
A mariner-Based Transposon System for In Vivo Random Mutagenesis of Clostridium difficile
Spores of Clostridium difficile Clinical Isolates Display a Diverse Germination Response to Bile Sal
Lipoprotein CD0873 Is a Novel Adhesin of Clostridium difficile
A synthetic biology approach towards improved cellulolytic activity of Clostridium acetobutylicum AT
Development of Clostridium difficile R20291DeltaPaLoc model strains and in vitro methodologies revea
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosi
Complete Genome Sequence of Geobacillus thermoglucosidasius NCIMB 11955, the Progenitor of a Bioetha
Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteoly
Disruption of the acetate kinase (ack) gene of Clostridium acetobutylicum results in delayed acetate
The Cold-Induced Two-Component System CBO0366/CBO0365 Regulates Metabolic Pathways with Novel Roles
The potential of clostridial spores as therapeutic delivery vehicles in tumour therapy
Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen intera
Clostridium difficile Genome Editing Using pyrE Alleles
CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii, an Autotrophic Gas-Fermenting
The role of toxin A and toxin B in Clostridium difficile infection
Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivati
The Cold-Induced Two-Component System CBO0366/CBO0365 Regulates Metabolic Pathways with Novel Roles
The role of flagella in Clostridium difficile pathogenicity.
A roadmap for gene system development in Clostridium
Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetob
A modular system for Clostridium shuttle plasmids. Journal of Microbiological Methods
Reconsidering the Sporulation Characteristics of Hypervirulent Clostridium difficile BI/NAP1/027
Riboswitch (T-box)-mediated Control of tRNA-dependent Amidation in Clostridium acetobutylicum Ration
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
A roadmap for gene system development in Clostridium
The diverse sporulation characteristics of Clostridium difficile clinical isolates are not associate
Sporulation studies in Clostridium difficile
Regulation of cel Genes of C. cellulolyticum: Identification of GlyR2, a Transcriptional Regulator R
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infe
A genetic assay for gene essentiality in Clostridium
Clostridium difficile spore germination: an update
Investigation of Second Primary Malignancies (SPM) in Multiple Myeloma (MM) Patients Treated with Le
The putative influence of the agr operon upon survival mechanisms used by Clostridium acetobutylicum
Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro
Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infe
SleC Is Essential for Germination of Clostridium difficile Spores in Nutrient-Rich Medium Supplement
Important Role of Class I Heat Shock Genes hrcA and dnaK in the Heat Shock Response and the Response
Two-Component Signal Transduction System CBO0787/CBO0786 Represses Transcription from Botulinum Neur
Comparison of culture based methods for the isolation of Clostridium difficile from stool samples in
A roadmap for gene system development in Clostridium
Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen intera
The emergence of ‘hypervirulence’ in Clostridium difficile
Precise Manipulation of the Clostridium difficile Chromosome Reveals a Lack of Association between t
Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum-evidence f
The Flagellin FliC of Clostridium difficile Is Responsible for Pleiotropic Gene Regulation during In
Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress
Co-infection and emergence of rifamycin resistance during a recurrent Clostridium difficile infectio
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection