Professor Guruprasad Aithal

Professor Guruprasad Aithal

Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH

+44 115 746 5124 View full bio
Deputy Director of the NIHR Nottingham BRC
GI & Liver Disorders Theme Lead
Professor of Hepatology, Head of Nottingham Digestive Diseases Centre

Biography

Professor Guruprasad P. Aithal graduated with MBBS from Kasturba Medical College, Manipal, MD (Internal Medicine) from Bangalore Medical College, Bengaluru, India and completed his specialist training in Gastroenterology in the Northern Deanery, UK. He received PhD from the University of Newcastle and was an International Fellow at the Medical University of South Carolina, Charleston, USA.

He is Professor of Hepatology and the Head of the Division for the Nottingham Digestive Diseases Centre, School of Medicine. He is also the Gastrointestinal & Liver Disorder Theme Lead for the National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and the University of Nottingham.

He is the Deputy Project Co-ordinator and work package lead of the ‘Translational Safety Biomarker Pipeline (TransBioLine)’ programme of the Innovation Medicines Initiative (IMI) of the European Union and the European Federation of Pharmaceutical Industries & Associations (EFPIA) (2019-24)

He is also the Hepatology lead for the National Institute for Health Research (NIHR) Health Technology Assessment programme: ‘Anti-TB drug hepatotoxicity and treatment reintroduction’ (2020-26).

Research Summary

Drug-induced liver injury (DILI): Genetic and environmental factors associated with drug-induced liver injury, non-invasive markers to detect and monitor hepatotoxicity.

Metabolic liver diseases: Interaction of dietary and genetic factors in the pathogenesis, non-invasive detection and stratification of non-alcohol and alcohol related liver diseases, interventions to prevent and resolve non-alcoholic steatohepatitis.

Non-invasive evaluation of liver and biliary disorders: Application of biomedical imaging methods to evaluate physiology, pathobiology and its consequences. Optimising endoscopic evaluation of hepato-pancreatico-biliary neoplacia; tools and techniques

Teaching Summary

Prof Aithal is an Associate Fellow of the Higher Education Academy (2019). He has been an invited faculty for post-graduate course in Europe, USA, Asia and Africa. He is also Joint Advisory Group for on GI Endoscopy (JAG) accredited trainer for advanced endoscopic biliary procedures.

Studies
Title Start Date Status
Pharmacogenetics of drug induced liver injury (DILIGEN) 1st June 2009 Ended
A 48-weeks phase 2, randomised, double blinded placebo controlled, parallel group, multi centre tria 1st February 2011 Ended
A pivotal study to evaluate the efficacy of GFT505 80mg and GFT505 160mg on steatohepatitis in patie 1st February 2013 Ended
A Phase 2 double blinded, randomised, placebo controlled dose-finding study to evaluate the safety t 1st February 2017
Pro-Euro-DILI Registry: Creation of a multicentre and multidisciplinary European registry of prospec 1st February 2016 In Recruitment
A Phase 3, double blind, Randomised, Long-Term, Placebo Controlled, Multicentre study Evaluating the 1st April 2016 In Recruitment
A two-part randomized, double-blind, placebo-controlled multicenter dose ranging and confirmatory st 11th April 2018 Active
Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & Validation of 20th May 2019 In Recruitment
Evaluation of the role of AST:ALT ratio, ELF markers and fibroscan in the detection of methotrexate 1st June 2014 In Recruitment
A Mechanistic Investigation into Drug and Chemical Induced Hypersensitivity Reactions 10th July 2019 Active
Effects of low glycemic index diet on hepatic lipids accumulation in relation to early life factors 24th February 2020 Active
Case control study evaluating the genetic factors associated with the development of non-alcoholic s 1st January 2012 In Recruitment
A single arm, two-stage, multi-centre, phase II clinical trial investigating the safety and activity 4th September 2015 Active
The NAFLD BioResource, part of the NIHR BioResource – A Research Study to Characterise Novel Clinica 15th January 2020 Active
Case-control Study Evaluating the Genetic Factors Associated with the Development of Non-alcoholic S 23rd November 2015 In Recruitment
The Evaluation of Portal Hypertension Using Quantitative Magnetic Resonance Imaging (MRQuee study 1st April 2013 In Recruitment
HCV Research UK MRI Study 1st April 2014 In Recruitment
Drug Induced Liver Injury Cohort in Nottingham (DILICIN) 1st January 2014 Ended
Magnetic Resonance Imaging in the evaluation of hepatic fibrosis:search for MRI biomarker (Mrker) 1st December 2009 Ended
The influence of ethnicity on non-alcoholic fatty liver disease in people of South Asian origin 1st August 2017 Active
Biomarkers of idiosyncratic drug-induced liver injury in patients taking Diclofenac 1st February 2011 Ended
Nottingham Digestive Diseases Biomedical Research Unit Research Tissue Bank 1st January 2015 In Recruitment
A cross-sectional study to assess the reliability of infrared thermography (IRT) in measuring brown 1st August 2017 Active
The Impact of Type 2 Diabetes and Exercise on Liver Fat Quality 1st September 2018 Active
Randomised evaluation of algorithm for Crohn’s treatment - Study 2 (REACT 2) 1st December 2014 In Recruitment
Effect of Carnitine supplementation on Liver steatosis, Insulin sensitivity, Plasma glucose homeosta 7th March 2018 In Recruitment
Fighting the fatty liver pandemic: Developing effective protocols & local expertise to deliver & eva 1st November 2018 Active
Double blind, randomised controlled trial to investigate the efficacy of ANTOX(vers)1.2 and MGCT (Ma 1st December 2011 Active
Magnetic resonance spectroscopy (MRS) Estimation of Glutathione flux in the Liver (MEGL) 1st August 2015 Active
NASH meal response study: The Study of Genetic Factors Involved in Post-Prandial Fat Processing and 1st July 2016 Active
The effects of an iso-energetic low glycemic index diet on liver fat accumulation and gut microbiota 7th August 2019 In Recruitment
Grants
Title Amount
Nottingham Molecular Pathology Node (NMPN) £2,400,000
Translational Safety Biomarker Pipeline €28M
Dietary evaluation and interventions in NAFLD in south indian community £9,904
Non-invasive detection, stratification and treatment of chronic liver disease in vulnerable elderly £134,746
Fighting the Fatty Liver Pandemic £248,321
EASL registry Grant £35,798.33
Telomere Length and Telomerase Activity £8,260
Drug-Induced Liver Injury £78,327
Prospective European Drug-Induced Liver Injury Registry (Pro-Euro-DILI Registry) 50’000 €
Functional characteristics of a rare MTTP mutation £9,850
Publications
Title
Dyspnoea in a patient with cirrhosis
Preoperative Drainage in Pancreatic Cancer
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I
End-stage methotrexate-related liver disease is rare andassociated with features of the metabolic sy
Genetic Basis of Drug-Induced Liver Injury: Present and Future
Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practic
HLA-B 14:01 and HLA-B 35:01 are associated with trimethoprim-sulfamethoxazole induced liver injury
Clinical and microbiological features of infection in alcoholic hepatitis: an international cohort s
A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis
The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South K
Post-transplant Outcome of Lean Compared to Obese Nonalcoholic Steatohepatitis in the United States:
Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines
Guidelines on the management of ascites in cirrhosis
The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort st
All-cause mortality in people with cirrhosis compared with the general population: a population-base
1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998-2009: A larg
Visual morphometry and three non-invasive markers in the evaluation of liver fibrosis in chronic liv
Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-c
Current and Future Magnetic Resonance Technologies for Assessing Liver Disease in Clinical and Exper
Hip fracture risk in patients with alcoholic cirrhosis: A population-based study using English and D
HLA associations with infliximab-induced liver injury
Advanced Preclinical Models for Evaluation of Drug Induced Liver Injury - Consensus Statement by the
Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic li
Efficacy of Recombinant Human Interleukin-10 in Prevention of Post-Endoscopic Retrograde Cholangiopa
Effectiveness of a nurse-led alcohol liaison service in a secondary care medical unit
Accurate non-invasive diagnosis and staging of non-alcoholic fatty liver disease using the urinary s
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl
The evaluation of portal hypertension using quantitative magnetic resonance imaging (MRI)
Acceptability of chronic liver disease screening in a UK primary care setting: a qualitative evaluat
Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active dem
The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overwe
Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Allel
Drug Development for Nonalcoholic Fatty Liver Disease: Landscape and Challenges
Investigation of Oxidative Stress-Related Candidate Genes as Risk Factors for Drug-Induced Liver Inj
High-resolution endoscopy and endoscopic ultrasound for evaluation of early neoplasia in Barrett’s e
How to tackle rising rates of liver disease in the UK
End-stage methotrexate-related liver disease is rare and associated with features of the metabolic s
The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver dise
Visual morphometry and three non-invasive markers in the evaluation of liver fibrosis in chronic liv
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and O
Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma
Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications
Of Potions, Poisons, Polygonum, and Pre-emptive Polymorphism
Obesity Is the Most Common Risk Factor for Chronic Liver Disease: Results From a Risk Stratification
Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steat
Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based s
Efficacy, Safety, and Predictive Factors for a Positive Yield of EUS-Guided Trucut Biopsy: A Large T
Hepatotoxicity related to antirheumatic drugs
Effect of prone positioning on cardiac output and liver blood flow in the awake healthy volunteer
Prevalence and Natural History of Histologically Proven Chronic Liver Disease in a Longitudinal Coho
Investigating the effects of an Oral Fructose Challenge on Hepatic ATP Reserves in Healthy Volunteer
HLA associations with infliximab-induced liver injury
Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Patho
The effect of prone positioning with surgical bolsters on liver blood flow in healthy volunteers
Drug-induced liver injury: recent advances in diagnosis and risk assessment
Effects of short-term energy restriction on liver lipid content and inflammatory status in severely
Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men
Pretreatment Lesions on Magnetic Resonance Imaging in Patients With Hepatitis C Virus Infection Diag
Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort
Effect of exercise intensity on circulating hepatokine concentrations in healthy men
Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK
Case Definition and Phenotype Standardization in Drug-Induced Liver Injury
The Road to a Successful Transjugular Intrahepatic Portosystemic Shunt (Tips) Service: Experience of
Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steat
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre
Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde chol
Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis i
Editorial: treating hepatorenal syndrome-a window and the views
Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions
Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of
Prevention and management of idiosyncratic drug-induced liver injury: Systematic review and meta-ana
Comparison of the reverse bevel versus Franseen type endoscopic ultrasound needle
Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based s
Mind the Gap
Abnormal liver tests in people aged 75 and above: prevalence and association with mortality
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver
A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histol
Liver-related outcomes in a large cohort of patients with Type 2 diabetes on insulin or sulphonylure
Multi organ assessment of Compensated Cirrhosis Patients using quantitative Magnetic Resonance Imagi
Natural History of Histologically-proven Alcohol Related Liver Disease: A systematic review
Commentary: non-alcoholic steatohepatitis-finding and minding the fire behind the smoke
Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy M
The antecedents of biliary cancer: a primary care case-control study in the United Kingdom
Preempting and preventing drug-induced liver injury
The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioner
Immune dysfunction and changes in intestinal morphology in patients with obstructive jaundice
Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practic
The quest for an evidence-based approach to surveillance for methotrexate-related hepatotoxicity: pr
The Development and Implementation of a Commissioned Pathway for the Identification and Stratificati
Transient elastography for screening of liver fibrosis: Cost-effectiveness analysis from six prospec
Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large
Fast-food hyper-alimentation and exercise restriction in healthy subjects
Development and evaluation of a nurse-led transient elastography service for the staging of hepatic
Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde chol
Prevalence of clinically significant liver disease within the general population, as defined by non-
Diffuse nesidioblastosis causing hyperinsulinemic hypoglycemia: the importance of pancreatic samplin
Safety and factors predicting diagnostic yield of EUS-guided trucut biopsy technique: a large single
A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo (13)C ma
Obesity Is the Most Common Risk Factor for Chronic Liver Disease: Results From a Risk Stratification
Large volume paracentesis: to do or where to do?
Human leukocyte antigen genetic risk factors of drug-induced liver toxicology
Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteer
Risk of Cardiovascular and Cerebrovascular Events in Primary Biliary Cirrhosis: A Population-Based C
Endoscopic-ultrasound-guided mural trucut biopsy in the investigation of unexplained thickening of e
Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associa
Regional anthropometric measures associated with the severity of liver injury in patients with non-a
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms
Metabolic Imaging in Non-Alcoholic Fatty Liver Disease: Applications of Magnetic Resonance Spectrosc
An analysis of rebleeding rates for variceal haemorrhage at a regional centre: what is the applicabi
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphism
Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis i
Gut Microbial Profile Is Associated With Residential Settings and Not Nutritional Status in Adults i
Prevalence and Natural History of Histologically Proven Chronic Liver Disease in a Longitudinal Coho
Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primar
Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a popula
Economic evaluation of a community-based diagnostic pathway to stratify adults for non-alcoholic fat
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a
Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A
Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging