Professor Guruprasad Aithal

Professor Guruprasad Aithal

Professor of Hepatology
Head of Nottingham Digestive Diseases Centre
Director of Biomedical Research Unit

+44 115 746 5124 View full bio
Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH

Professor Aithal has been a Consultant Hepatobiliary Physician at Nottingham University Hospitals NHS trust since 2001. He is the Lead Director of the NIHR Nottingham Digestive Diseases Biomedical Research Unit, and the Head of Division for the Nottingham Digestive Diseases Centre, University of Nottingham. He is also a Professor of Hepatology at The University of Nottingham.

Professor Aithal’s interests centre around translational research in the following areas:

  • Drug-induced liver injury (causality assessment, outcome, genetic and environmental factors that affect drug metabolism and hepatotoxicity).
  • Non-alcoholic fatty liver disease (mechanisms, biomarkers, lifestyle and pharmacological interventions).
  • Epidemiology of liver and biliary disease (cause and consequences)
  • Hepatobiliary imaging (quantitative magnetic resonance imaging to evaluate chronic liver disease, novel techniques to assess the degree of liver injury and impairment of function).

His future research plans include the following:

  • Quantitative and dynamic MRI techniques in chronic liver disease
  • Dietary, life style and genetic factors associated with the non-alcoholic fatty liver disease (NAFLD)
  • Mechanisms and efficacy evaluation of interventions in NASH
  • Identification, development and validation of markers of liver injury
Studies
Title Start Date Status
Biomarkers of idiosyncratic drug-induced liver injury in patients taking Diclofenac 1st February 2011 Ended
Randomised evaluation of algorithm for Crohn’s treatment - Study 2 (REACT 2) 1st December 2014 In Recruitment
Double blind, randomised controlled trial to investigate the efficacy of ANTOX(vers)1.2 and MGCT (Ma 1st December 2011 Active
A single arm, two-stage, multi-centre, phase II clinical trial investigating the safety and activity 4th September 2015 Active
Pharmacogenetics of drug induced liver injury (DILIGEN) 1st June 2009 Ended
A 48-weeks phase 2, randomised, double blinded placebo controlled, parallel group, multi centre tria 1st February 2011 Ended
A pivotal study to evaluate the efficacy of GFT505 80mg and GFT505 160mg on steatohepatitis in patie 1st February 2013 Ended
Case-control Study Evaluating the Genetic Factors Associated with the Development of Non-alcoholic S 23rd November 2015 In Recruitment
The Evaluation of Portal Hypertension Using Quantitative Magnetic Resonance Imaging (MRQuee study 1st April 2013 In Recruitment
HCV Research UK MRI Study 1st April 2014 In Recruitment
NASH meal response study: The Study of Genetic Factors Involved in Post-Prandial Fat Processing and 1st July 2016 Active
Evaluation of the role of AST:ALT ratio, ELF markers and fibroscan in the detection of methotrexate 1st June 2014 In Recruitment
Magnetic Resonance Imaging in the evaluation of hepatic fibrosis:search for MRI biomarker (Mrker) 1st December 2009 Ended
Pro-Euro-DILI Registry: Creation of a multicentre and multidisciplinary European registry of prospec 1st February 2016 In Recruitment
A Phase 3, double blind, Randomised, Long-Term, Placebo Controlled, Multicentre study Evaluating the 1st April 2016 In Recruitment
Case control study evaluating the genetic factors associated with the development of non-alcoholic s 1st January 2012 In Recruitment
Drug Induced Liver Injury Cohort in Nottingham (DILICIN) 1st January 2014 Ended
Magnetic resonance spectroscopy (MRS) Estimation of Glutathione flux in the Liver (MEGL) 1st August 2015 Active
Nottingham Digestive Diseases Biomedical Research Unit Research Tissue Bank 1st January 2015 In Recruitment
A Phase 2 double blinded, randomised, placebo controlled dose-finding study to evaluate the safety t 1st February 2017
Publications
Title
Dyspnoea in a patient with cirrhosis
Preoperative Drainage in Pancreatic Cancer
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I
End-stage methotrexate-related liver disease is rare andassociated with features of the metabolic sy
1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998-2009: A larg
Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Patho
Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde chol
The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort st
All-cause mortality in people with cirrhosis compared with the general population: a population-base
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl
The evaluation of portal hypertension using quantitative magnetic resonance imaging (MRI)
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre
Efficacy of Recombinant Human Interleukin-10 in Prevention of Post-Endoscopic Retrograde Cholangiopa
Effectiveness of a nurse-led alcohol liaison service in a secondary care medical unit
End-stage methotrexate-related liver disease is rare and associated with features of the metabolic s
Liver-related outcomes in a large cohort of patients with Type 2 diabetes on insulin or sulphonylure
High-resolution endoscopy and endoscopic ultrasound for evaluation of early neoplasia in Barrett’s e
How to tackle rising rates of liver disease in the UK
Prevalence and Natural History of Histologically Proven Chronic Liver Disease in a Longitudinal Coho
Investigating the effects of an Oral Fructose Challenge on Hepatic ATP Reserves in Healthy Volunteer
Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Patho
Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based s
Efficacy, Safety, and Predictive Factors for a Positive Yield of EUS-Guided Trucut Biopsy: A Large T
Hepatotoxicity related to antirheumatic drugs
Effect of prone positioning on cardiac output and liver blood flow in the awake healthy volunteer
Lack of Efficacy of an Inhibitor of PDE4 in Phase 1 and 2 Trials of Patients With Nonalcoholic Steat
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre
Case Definition and Phenotype Standardization in Drug-Induced Liver Injury
The Road to a Successful Transjugular Intrahepatic Portosystemic Shunt (Tips) Service: Experience of
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver
A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histol
Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steat
Incidence and prevalence of cirrhosis in the United Kingdom, 1992-2001: A general population-based s
Mind the Gap
Abnormal liver tests in people aged 75 and above: prevalence and association with mortality
Immune dysfunction and changes in intestinal morphology in patients with obstructive jaundice
Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practic
The quest for an evidence-based approach to surveillance for methotrexate-related hepatotoxicity: pr
Visual morphometry and three non-invasive markers in the evaluation of liver fibrosis in chronic liv
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and O
The antecedents of biliary cancer: a primary care case-control study in the United Kingdom
Preempting and preventing drug-induced liver injury
The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioner
Genetic Basis of Drug-Induced Liver Injury: Present and Future
Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practic
The effect of prone positioning with surgical bolsters on liver blood flow in healthy volunteers
Fast-food hyper-alimentation and exercise restriction in healthy subjects
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms
Development and evaluation of a nurse-led transient elastography service for the staging of hepatic
A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo (13)C ma
Diffuse nesidioblastosis causing hyperinsulinemic hypoglycemia: the importance of pancreatic samplin
Safety and factors predicting diagnostic yield of EUS-guided trucut biopsy technique: a large single
Human leukocyte antigen genetic risk factors of drug-induced liver toxicology
Risk of Cardiovascular and Cerebrovascular Events in Primary Biliary Cirrhosis: A Population-Based C
Endoscopic-ultrasound-guided mural trucut biopsy in the investigation of unexplained thickening of e
Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde chol
Regional anthropometric measures associated with the severity of liver injury in patients with non-a
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphism
An analysis of rebleeding rates for variceal haemorrhage at a regional centre: what is the applicabi
Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteer
Prevalence and Natural History of Histologically Proven Chronic Liver Disease in a Longitudinal Coho
Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primar
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a
The detection of oesophageal varices using a novel, disposable, probe-based transnasal endoscope: a
Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging