Dr Monaghan came to Nottingham in 2006 and took up the position as the first NIHR Academic Clinical Fellow in Gastroenterology. Alongside clinical training, she worked in the laboratory of Professor Yash Mahida. She was subsequently awarded a Wellcome Trust Clinical Training Fellowship in 2009 to study the host immune response to C. difficile toxins A and B, the principal virulence factors involved in disease pathogenesis, and was awarded a PhD in 2013.
She currently holds an NIHR Academic Clinical Lectureship in Gastroenterology in the Nottingham Digestive Diseases Biomedical Research Unit. In December 2013, she was awarded an Academy of Medical Sciences Starter Grant for Clinical Lecturers to study novel antimicrobial treatments for C. difficile infection (CDI), utilising a human in vitro gut model of CDI developed by Professor Mark Wilcox, University of Leeds. In collaboration with the Immunology Department at UoN, Dr Monaghan is also adapting a microarray platform to investigate antigen-specific antibody responses in the circulation of patients with CDI. Recently, she has established collaborations with Dr Jeffrey Beekman, University Medical Centre Utrecht, and Dr Nick Hannan, University of Nottingham to determine the utility of a human stem-cell derived intestinal organoid culture model in studying C. difficile pathogenesis. We hope to use this model to develop and test new therapies for CDI.
|An investigation of the prevalence and dynamics of carriage of C. difficile in different IBD outpati||1st January 2014||Active|