Dr Jane Grove

Dr Jane Grove

Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH

+44 115 924 9924 View full bio
Assistant Professor

I am an Assistant Professor in the Hepatology Group in the NIHR Nottingham Biomedical Research Centre and the MRC-funded Nottingham Molecular Pathology Node (http://www.nmpn.info/). My research includes translational research projects in the following areas: Drug-induced liver injury (assessment, genetic and environmental factors that affect drug metabolism and hepatotoxicity).

Non-alcoholic fatty liver disease and alcoholic liver disease (mechanisms and biomarkers of liver injury).

Genetic determinants of liver disease.

Development and validation of markers of oxidative stress in the evaluation of acute liver injury and chronic liver diseases.

Non-invasive assessment of liver fibrosis.

Clinical application of liver biomarkers.

Experimental diagnostics of chronic liver injury.

I am Divisional Safety Officer and Human Tissue Authority Person Designate for the Nottingham Digestive Diseases Centre.

I am a member of the UK Stratified Medicine and Pharmacogenetics Committee and am involved in developing Biobank networks.

Research Experience:

Analysis of genetic determinants of the development of alcoholic liver disease. (Newcastle University)

Improvement of E. coli nitroreductase by mutagenesis: a route to optimization of virus- directed enzyme-prodrug cancer therapy. (Cobra Therapeutics)

DNA double-strand break repair in E. coli. (Nottingham University)

Role of novel Type IV secretion systems in Helicobacter pylori virulence. (Nottingham University)

Degree: Molecular Biology and Biochemistry (Durham University)

PhD: Escherichia coli genes essential for formate-dependent nitrite reduction, cytochrome c biosynthesis and periplasmic nitrate reduction. (Birmingham University)

Expertise Summary:

Quantification of circulating biomarkers including Luminex multiplex analysis on Bioplex 200

Characterisation and phenotyping of patient cohorts and analysis of clinical data

Expression analyses including assessment of liver tissue markers

Molecular genetics including detection of polymorphisms, cloning, PCR and sequencing

Biochemistry (including protein expression, purification and analysis)

Biobanking: setting up a Research Tissue Bank, clinical sample collection, storage and cataloging/databases

Microbiology: specialist in E.coli and H.pylori manipulation and phenotyping

Publications
Title
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphism
Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug
MR Measures of Small Bowel Wall T2 Are Associated With Increased Permeability
A role for the tfs3 ICE-encoded type IV secretion system in pro-inflammatory signalling by the Helic
Analysis of genotyping for predicting liver injury marker, Procollagen III in persons at risk of non
Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its s
Human leukocyte antigen genetic risk factors of drug-induced liver toxicology
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and O
Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma
Gut Microbial Profile Is Associated With Residential Settings and Not Nutritional Status in Adults i
Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Allel
In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnost
Genome-Wide Association Studies in Drug-Induced Liver Injury: Step Change in Understanding the Patho
Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications
Accurate non-invasive diagnosis and staging of non-alcoholic fatty liver disease using the urinary s
Lower gut microbiome diversity and higher abundance of proinflammatory genus Collinsella are associa
The Evaluation and Use of a Food Frequency Questionnaire Among the Population in Trivandrum, South K
Analysis of genotyping for predicting liver injury marker, procollagen III in persons at risk of non
Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort