Dr Jane Grove

Dr Jane Grove

Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH

+44 115 924 9924 View full bio
Assistant Professor

I am a research scientist in the Hepatology Group (Guru Aithal & Neil Guha) in the NIHR Nottingham Digestive Diseases Biomedical Research Unit. I am involved in translational research in the following areas:

  • Drug-induced liver injury (assessment, genetic and environmental factors that affect drug metabolism and hepatotoxicity).
  • Non-alcoholic fatty liver disease (mechanisms and biomarkers of liver injury).
  • Hepatobiliary imaging (assessment of degree of liver injury).
  • Development and validation of markers of oxidative stress in the evaluation of acute liver injury and chronic liver diseases.
  • Non-invasive assessment of liver fibrosis.
  • Clinical application of liver biomarkers.
  • Experimental diagnostics of chronic liver injury.

I am currently safety officer and Human Tissue Authority Person Designate for the Nottingham Digestive Diseases Centre.

I am a member of the UK Stratified Medicine and Pharmacogenetics Committee and am involved in developing Biobank networks.

Research Experience:

Analysis of genetic determinants of the development of alcoholic liver disease. (Newcastle University)

Improvement of E. coli nitroreductase by mutagenesis: a route to optimization of virus- directed enzyme-prodrug cancer therapy. (Cobra Therapeutics)

DNA double-strand break repair in E. coli. (Nottingham University)

Role of novel Type IV secretion systems in Helicobacter pylori virulence. (Nottingham University)

Degree: Molecular Biology and Biochemistry (Durham University)

PhD: Escherichia coli genes essential for formate-dependent nitrite reduction, cytochrome c biosynthesis and periplasmic nitrate reduction. (Birmingham University)

Expertise Summary

Biobanking: setting up a Research Tissue Bank, clinical sample collection, storage and cataloging/databases

Quantification of circulating biomarkers including Luminex multiplex analysis on Bioplex 200

Molecular genetics including detection of polymorphisms, cloning, PCR and sequencing

Biochemistry (including protein expression, purification and analysis)

Microbiology: specialist in E.coli and H.pylori manipulation and phenotyping