Using non- contrast sequences to characterise and quantify the small bowel wall in healthy volunteers (REPEAT study)

1st January 2018 - ongoing

Status: In Recruitment

Specialism: Imaging, MR Imaging, Lower GI.

Team: Dr Caroline HoadDr Gordon MoranProfessor Penny Gowland.

The collaboration between the SPMIC and the Nottingham Digestive Diseases Centre and NIHR BRC have been developing methods to quantify changes in inflammation and fibrosis of the small bowel wall related to diseases such as Inflammatory bowel disease (Crohn’s) and liver cirrhosis. Before any of this work can be applied in patient cohorts to look both at disease activity and response to treatment the reliability of the measurements needs to be assessed. This is best carried out in healthy volunteers as they are easier to recruit and less likely to have additional medical complications which may alter the accuracy of the measurement beyond that which is being investigated. The quantitative sequences which have been or are currently being developed are: relaxometry T1 and T2 measurements, magnetisation transfer imaging and diffusion imaging using the IVIM methodology.

To carry out these measurements on the bowel wall subjects need to ingest 1 Litre of bowel preparation (2.5% w/w mannitol and 0.2 % locust bean gum powder dissolved in water). This is consumed over a 40-50 minute time period immediately prior to scanning. This solution distends the small bowel allowing the bowel wall to become more easily identifiable on the MR images, however induces significant motion of the bowel wall. An injection of an anti-spasmodic agent (Buscopan) reduces the motion of the bowel wall to allow the position of the wall segments to remain consistent when images are being acquired.

The aim of this study is to evaluate the repeatability in human volunteers of the quantitative bowel wall parameters measured from the different MRI sequences following the bowel preparation and administration of the anti-spasmodic agent.

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caroline-hoad Dr Caroline Hoad
dr-gordon-moran Dr Gordon Moran Dr Moran did his undergraduate medical training at University of Malta Medical School and was awarded an MD in 1999. He completed his basic postgraduate training at St. Luke's Hospital in Malta and gained membership of the Royal College of Physicians of…
professor-penny-gowland Professor Penny Gowland Developing quantitative MRI for biomedical applications. I am particularly interested in exploiting the capabilities of functional and anatomical ultra-high field MRI in neuroscience, in using the increased contrast to noise ratio available at ultrahigh…
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