The influence of ethnicity on non-alcoholic fatty liver disease in people of South Asian origin

1st August 2017 - ongoing

Status: Active

Specialism: Liver.

Team: Professor Guruprasad AithalDr Jane Chalmers.

This study aims to identify ethnic differences that contribute to the increased risk of the hepatic manifestation of the metabolic syndrome (NAFLD) in South Asian populations both in the UK and in India, in comparison to Caucasians.

It will establish four UK cohorts; UK South Asian NAFLD, UK Caucasian NAFLD, UK South Asian controls and UK Caucasian controls. These cohorts will be studied alongside two Indian cohorts (NAFLD and controls). Participants will attend a single study visit, where they will undergo assessment of basic metabolic parameters (fasting lipids, insulin, glucose cortisol etc), body composition (via anthopometry and bioimpedance) and will complete a food frequency and physical activity questionnaire. Participants will also have an assessment of their brown fat activity via thermal imaging.

Overall, this study aims to provide information on the impact of diet, exercise habits, general body composition and brown fat activity and their relevant impact on the presence of NAFLD between ethnic groups.

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guruprasad-aithal Professor Guruprasad Aithal Professor Aithal has been a Consultant Hepatobiliary Physician at Nottingham University Hospitals NHS trust since 2001. He is the Head of the NIHR Nottingham Digestive Diseases Biomedical Research Centre, and the Head of Division for the Nottingham…
Dr Jane Chalmers
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