The effects of an iso-energetic low glycemic index diet on liver fat accumulation and gut microbiota composition in patients with non- alcoholic fatty liver disease (NAFLD)
7th August 2019 - ongoing
Status: In Recruitment
Specialism: Liver, Non-Alcoholic Fatty Liver Disease (NAFLD).
Chief Investigator: Professor Guruprasad Aithal
Local Researchers: Amina Al-Awadi, Dr. Jane Grove, Dr. Moira Taylor and Dr Ana Valdes
Non-alcoholic fatty liver disease (NAFLD) is a growing global health problem which may arise as a consequence of dietary habits and inactive lifestyle. It develops when a person’s liver cells consist of more than 5% of fat. People with NAFLD often suffers from recurrent high blood sugar which puts them at high risk of developing diabetes. We think that liver fat accumulation is highly affected by eating certain foods with high Glycemic index (GI) foods (meaning that they result in higher blood sugar levels soon after being eaten) on daily basis. So, a diet containing more foods with low GI could be beneficial to treat or manage NAFLD. The GI of food is a ranking system of carbohydrates on a scale from 0- 100 depending on how quickly each type of carbohydrate raise blood sugar after eating. Foods with GI ˃70 are ranked as high GI foods, whereas foods with GI ˂ 55 are low GI foods. Consumption of a large amount or proportion of high GI foods is linked to higher levels of specific bacteria in the gut (called gut microbiota) which may trigger increased liver fat accumulation.
What is the purpose of the study?
The purpose of this study is to compare liver fat levels in people with NAFLD after following a low GI diet versus a high GI diet. We propose two different diets, each to be followed for 2 weeks by all study participants. We will also examine their gut bacteria composition before and after each period. This will help us to develop treatment and strategies to manage the factors that increase NAFLD progression.
We are looking for adults:
- With non-alcoholic fatty liver disease (NAFLD).
- Male and female between 18-65 years old.
- Not participating in any other trial or on any special diets (e.g. vegetarian).
- Not on any medication related to diabetes or gastrointestinal disorders.
- Not having any food allergies or intolerance to the food on the study diet.
- Willing to stop taking probiotics, foods high in fibre etc. 1 week prior to starting and during the course of the study.
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|Professor Guruprasad Aithal||Biography Professor Guruprasad P. Aithal graduated with MBBS from Kasturba Medical College, Manipal, MD (Internal Medicine) from Bangalore Medical College, Bengaluru, India and completed his specialist training in Gastroenterology in the Northern…|
|Dr Jane Grove||I am an Assistant Professor in the Hepatology Group in the NIHR Nottingham Biomedical Research Centre and the MRC-funded Nottingham Molecular Pathology Node (http://www.nmpn.info/). My research includes translational research projects in the following…|