The effect of oral feeding on gastric emptying, small bowel water content, superior mesenteric artery blood flow, plasma hormone concentrations and blood volume in obese and healthy weight subjects (Appetite Study)

3rd June 2018 - ongoing

Status: In Recruitment

Specialism: Surgical.

Team: Professor Dileep Lobo.

Name of Investigators:

Liz Simpson, Senior Research fellow, University of Nottingham

Debbie Bush, GI Clinical Physiologist, University of Nottingham

Damian Bragg, Clinical Research Fellow, University of Nottingham, MBChB, MRCS

Dileep Lobo, Professor and Reader in Surgery, University of Nottingham DM FRCS

Background

Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese.

We will be investigating 12 people with obesity and comparing them to 12 people of normal build, to look at how quickly food empties out of the stomach (gastric emptying) and travels through the gut, what the blood flow to the gut is, and also to examine the hormones involved in how full people feel after eating. In order to do this, we will be using a magnetic resonance imaging (MRI) scanner, and performing blood tests.

The rate of gastric emptying may have an impact on satiety (how full one feels) and has been implied in the development of obesity. This effect has been shown to impact subsequent meal intake to a greater degree in overweight subjects, and may be due to a difference in gastric emptying of food in overweight individuals, or to hormones such as ghrelin, GLP-1, and PYY.

The study involves an MRI scan and blood tests before and after eating a pasta meal. Only one study visit.

For more information and how you can participate, please contact Debbie Bush or Liz Simpson:

debbie.bush@nottingham.ac.uk or liz.simpson@nottingham.ac.uk

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professor-dileep-lobo Professor Dileep Lobo Dileep Lobo is Professor of Gastrointestinal Surgery at the University of Nottingham and Consultant Hepatopancreaticobiliary Surgeon at Queens Medical Centre, Nottingham, UK. He qualified from Bangalore University, India and has trained as a surgeon in…
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