Reduced Intestinal Motility in Inflammatory Crohn’s Disease (MIC 2)

1st May 2015 - ongoing

Status: In Recruitment

Specialism: Lower GI.

Team: Dr Gordon Moran.

Crohn’s disease (CD) may present with symptoms of bloating, nausea, anorexia, and weight loss.

Enteroendocrine cells (EEC) constitute 1% of the cells lining the intestinal mucosa. They play a pivotal role in orchestrating gastrointestinal tract physiology by secreting multiple hormones that control intestinal functions. EC hormones, Cholecystokinin, Glucagon-like peptide-1 and polypeptide YY delay gastric emptying and small bowel transit. Recent data shows that in active CD there is a significant EC hyperplasia and an increase in postprandial EC peptide hormone release correlating to patient symptoms of bloating and nausea. Technological advances now allow us to measure gastrointestinal motility by using functional magnetic resonance imaging techniques.

We hypothesize that in CD with an inflammatory phenotype a) CD-related symptoms of abdominal bloating, nausea and loss of appetite are caused by altered gastrointestinal motility b) these changes are associated with EEC hyperplasia and altered postprandial EEC peptide release.

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