Predicting Acute-on-Chronic Liver Failure in Cirrhosis

2nd March 2017 - ongoing

Status:

Specialism: Liver, Cirrhosis & Consequences.

Team: Dr Steve Ryder.

The CANONIC Study consisted in a 28-day detailed prospective observational investigation in patients admitted to hospital for the treatment of an acute decompensation of cirrhosis. The main aim of the CANONIC study was to characterize acute-on-chronic liver failure (ACLF) regarding diagnostic criteria, stages and natural history up to one year of follow up. Three quarters of the ACLF-patients (in total ca. 400) recruited in the CANONIC study presented with ACLF at enrolment. Therefore, the critical period prior to ACLF development and possible predictors could not be sufficiently analyzed in these patients due to the study aim and design. Moreover, the limited knowledge about the ACLF syndrome itself rendered the prospective and detailed analysis of predictors for the development of ACLF impossible.

The PREDICT Study is therefore designed to prospectively observe patients with Acute Decompensation (AD) at risk of developing ACLF within three months and to discover clinical, laboratory and patho-physiological (using prospective ancillary studies) predictors and mechanisms involved in the development and clinical course of ACLF, which might help to prevent and treat ACLF.

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