MRI assessment of mode of action of Bisacodyl, single dose (MODS)

30th January 2020 - ongoing

Status: In Recruitment

Specialism: Imaging, MR Imaging.

Team: Professor Robin SpillerDr Maura CorsettiDr Luca MarcianiProfessor Penny GowlandDr Neele Dellschaft.

What is the purpose of this study?

The study is aimed at helping us better understand how bisacodyl works in the body. Bisacodyl is a common laxative to treat constipation. We can tell a lot from looking at your bowels using magnetic resonance imaging (MRI). This study compares images of your bowels when you take 5 mg bisacodyl or a placebo (dummy pill).

What does it involve?

You would be in this study for about 2-3 months.

It requires 9 visits: 1 for screening to determine if you are eligible to take part, and then two arms of the study each requiring 4 visits. Each arm consists of confirmation of eligibility, a full MRI study day and 2 short MRI study days, see diagram below. There will be a gap between the two parts of approximately 2 weeks (called the “wash-out period”) to allow any effect of treatment to wear off while you will continue your normal activities.

Overall you will be having a total of 18 MRI scans. These do not harm you but if you have specific metal in your body you may not be able to have MRI scans. We also ask you to keep a stool diary throughout the study and give us a total of six stool samples. During the long study days we will also give you a standardised meal: rice pudding with raspberry jam and bran with some orange juice.

For more information and how you can participate please contact Lesley Martin by email: lesley.martin@nottingham.ac.uk or by phone: 0115 95 14747 please mention the study name: MODS

People
Photo Name Bio
professor-robin-spiller Professor Robin Spiller Professor Spiller is Professor of Gastroenterology in the NIHR Nottingham Biomedical Research Centre at the University of Nottingham. Past Editor of Gut (2003-2009) and member of the Board of the Rome Foundation (2000-2015), he twice edited the…
dr-maura-corsetti Dr Maura Corsetti Dr Maura Corsetti is a Clinical Associate Professor in Gastroenterology at the University of Nottingham. She obtained her Specialization (2000) and PhD (2004) at the "Universita' degli Studi di Milano", Italy. During her PhD she worked for two years…
dr-luca-marciani Dr Luca Marciani I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships…
professor-penny-gowland Professor Penny Gowland Developing quantitative MRI for biomedical applications. I am particularly interested in exploiting the capabilities of functional and anatomical ultra-high field MRI in neuroscience, in using the increased contrast to noise ratio available at ultrahigh…
dr-neele-dellschaft Dr Neele Dellschaft Neele Dellschaft is a research fellow at the Sir Peter Mansfield Imaging Centre. Coming from a back ground in physiology she has side-stepped into work using MRI scans in 2017, and is now working on projects with clinicians in both gastroenterology and…
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