Mode of action of Moviprep:impact on distribution of intestinal fluid and colonic microbiota (Moviprep 2)

1st March 2012

Status: Ended


Team: Professor Robin Spiller.

Constipation is a very common disorder within the population, occurring in almost everyone at some point in their lives. Severe, chronic constipation can be debilitating and often patients are not satisfied with the treatment options which include: dietary changes, life style changes and the use of a laxative. Some of those patients with particularly severe symptoms report that they have not responded to the use of laxatives in the past.

At the University of Nottingham we have developed a new imaging procedure, using MRI, which allows us to visualise the complex structures of the bowel in patients with constipation and to monitor the response to a laxative. By comparing the structure and function of the bowel in patients with constipation to healthy volunteers, we may be able to better understand this disease and how to target treatment. In this study would like to recruit 48 patients with chronic constipation, to research how the bowels of patients with chronic constipation respond to 1 litre of a common laxative preparation, Moviprep.

We predict that the constipated patients will have an initial larger colonic volume but the movement of the laxative through the bowel will not be as effective as in healthy volunteers.

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professor-robin-spiller Professor Robin Spiller Robin's main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. He has twice edited the British Society of…
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