Host and viral factors associated with outcomes of infection with hepatitis C virus (HCV Research UK)

1st March 2012

Status: Ended

Specialism: Liver.

Team: Professor Will Irving.

HCV Research UK

Host and Viral Factors Associated with Outcomes of infection with hepatitis C virus

Observational Study of 10,000 patients with hepatitis C virus (HCV) infection to investigate the role of host and viral factors in determining the clinical outcome, in order to improve management and treatment algorithms in the UK.

Funded by Medical Research Foundation (2012 to 2016)

Although the virology and clinical features of chronic HCV infection have been intensively studied, a number of unresolved questions remain. These include:

  • The mechanisms underlying spontaneous viral clearance, which occurs in up to 40% of those who are exposed to infection
  • Determinants (host, viral, environmental) underlying the variable natural history of infection (slow versus rapid progression of fibrosis)
  • The outcome beyond 30 years and factors underlying development of decompensated cirrhosis and hepatocellular carcinoma
  • The host and viral factors that influence the response to current antiviral therapies

Addressing such questions is fundamental to both a biological understanding of the effects of HCV as well as to the development of clear management guidelines for infected patients overall, and of individual patient-centered care.

The primary aims of HCV Research UK are:

  1. Recruit a cohort of10,000 HCV-infected individuals from Hospital-based, Liver/HCV clinics throughout the UK.
  2. Collect clinical data and biological samples from those individuals to store in a Clinical Database and Research Biobank to support future research and thereby improve patient care.
  3. Use the data and samples in an initial study to investigate the role of a number of host and viral factors in disease outcomes such as spontaneous clearance vs chronic infection; sustained virological response vs non-response to current standard of care therapy; development of cirrhosis; development of hepatocellular carcinoma.
Our Team - Management Committee
Prof William Irving Co-Chief Investigator, University of Nottingham / Queen’s Medical Centre, Nottingham
Dr John McLauchlan Co-Chief Investigator, MRC-Centre for Virus Research, Glasgow
Sarah McDonald Biobank Manager, MRC-Centre for Virus Research, Glasgow
Bryony Wilkes Project Co-ordinator, University of Nottingham
Liz Holtham Data Co-ordinator, University of Nottingham
Dr Sharon Hutchinson Bio-informatics, University of Strathclyde, / Health Protection Scotland
Prof Graham Foster Queen Mary’s University of London, The London Hospital
Dr John Dillon University of Dundee / Ninewells Hospital and Medical School, Dundee
People
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professor-will-irving Professor Will Irving Clinical virology, especially in relation to viral hepatitis and the human herpes viruses. This encompasses diagnosis, management and pathogenesis of disease.
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