HCV Research UK MRI study

1st April 2014 - ongoing

Status: In Recruitment

Specialism: Liver.

Team: Professor Guruprasad AithalProfessor Neil GuhaProfessor Will IrvingDr Stephen RyderDr Susan FrancisProfessor Penny GowlandChris BradleyEleanor CoxAndrea Bennett.

Funded by NIHR (2014 to 2018)

New directly acting antivirals (DAAs) for the treatment of hepatitis C became available to patients with advanced cirrhosis under the compassionate use Early Access Programme approved by NHS England. Now treatment with these new DAAs has been approved by NICE for patients with cirrhosis. DAAs are taken for just a few weeks, are very effective at treating Hepatitis C and have remarkably few side effects. At the moment, only a small number of patients with Hepatitis C are eligible to have these new treatments. The purpose of this study is to assess what effect the new DAA treatments for Hepatitis C has on the liver in the short and long-term. We will use MRI (Magnetic Resonance Imaging) scans to look at the liver before and after treatment. MRI is an established way of taking pictures of the body. It is painless, non-invasive, does not use any radiation, and is commonly used to get detailed pictures of the brain, heart or liver. In Nottingham, we are using MRI scans to assess changes related to scarring in the liver and associated blood vessels.We have active patient involvement in this study to design the study so it fits around usual clinical appointments and make the study information easy to understand

Tests Involved

Patients taking part in the study will be invited to meet their Hepatitis C nurse and the research team at the NIHR Nottingham Digestive Diseases Biomedical Research Unit three times: at the start of treatment, at the end of treatment and when they find out if the treatment has worked. At each of these three visits they will have:

  • Research and routine blood tests
  • Fibroscan – a scan similar to ultrasound measuring how stiff a person’s liver is
  • MRI scan

If you are interested in taking part or want to find out more, please discuss it with your viral hepatitis nurse or consultant. Please feel free to contact us with any questions or to request further information:

Angela Andrew (Research Nurse)


Tel: 0115 924 9924 Ext64415

Photo Name Bio
guruprasad-aithal Professor Guruprasad Aithal Biography Professor Guruprasad P. Aithal graduated with MBBS from Kasturba Medical College, Manipal, MD (Internal Medicine) from Bangalore Medical College, Bengaluru, India and completed his specialist training in Gastroenterology in the Northern…
neil-guha Professor Neil Guha Dr Neil Guha is a Clinical Associate Professor in Hepatology at the University of Nottingham. He trained at Guy's and St. Thomas's hospitals and began his postgraduate career in hepatology at St. Mary's Hospital, London. His doctoral thesis, awarded by…
professor-will-irving Professor Will Irving Clinical virology, especially in relation to viral hepatitis and the human herpes viruses. This encompasses diagnosis, management and pathogenesis of disease.
dr-steve-ryder Dr Stephen Ryder
Dr Susan Francis My research has centred on developing Magnetic Resonance Imaging (MRI) methods for biomedical applications, over the last ~ 15 years in this field. This has included the application and development of functional magnetic resonance imaging (fMRI)…
professor-penny-gowland Professor Penny Gowland Developing quantitative MRI for biomedical applications. I am particularly interested in exploiting the capabilities of functional and anatomical ultra-high field MRI in neuroscience, in using the increased contrast to noise ratio available at ultrahigh…
Chris Bradley
Eleanor Cox
andrea-bennett Andrea Bennett
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