Functional Magnetic Resonance Imaging (MRI) in assessing dynamic changes induced by hypercapnia,hyperoxia and standard meal challenge in chronic liver disease (MRCO2)

1st January 2014

Status: Ended

Specialism: Liver.

Team: Dr Neil Guha.

Death from chronic liver disease has doubled in the UK over the last decade. The current ‘liver tests’ only identify liver injury when the damage is at an advanced stage. They neither estimate the degree of injury accurately nor help judge the clinical outcome in these patients. In very advanced liver disease (cirrhosis), the test used to assess outlook (prognosis) or response to treatment is invasive, expensive and only available in limited centres.

We are developing novel non-invasive magnetic resonance imaging (MRI) techniques to assess the changes in the liver in patients with chronic liver disease and cirrhosis.

In this study, we aim to assess the dynamic changes in liver blood flow and perfusion following the ingestion of a liquid meal and inhalation of high pressures of oxygen and carbon dioxide.

We will study the difference in these dynamic responses between healthy subjects and patients with chronic liver disease.

For any further information regarding this study, please contact Dr. Naaventhan Palaniyappan, Clinical Research Fellow in Hepatology.

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