Effect of physical form of apples on gastrointestinal function and satiety: a MRI study (APPLE Study)

1st February 2016 - ongoing

Status: In Recruitment

Specialism: Imaging, MR Imaging, Lower GI, Upper GI, Food & Function.

Team: Professor Robin SpillerShanthi KrishnasamyDr Luca Marciani.

Eating exactly the same foods but in different physical forms (solid, puree or juice) may have an effect on how people feel after eating. A study from the 1970s showed that if people eat a whole apple they will feel full for longer than when they eat it juiced. This is probably because the different forms of food will change the way nutrients are delivered to the bowel and how, in turn, the body responds to these nutrients. Some of the nutrients are sugars that can be fermented in the colon and this is known to induce gut symptoms such as bloating, diarrhoea and pain in some people. Avoiding these sugars in the diet usually works but it is not well understood why.

We would like to investigate this effect further using our special MRI imaging techniques that allow us to image foods in the body. We plan a pilot study in healthy volunteers. We will feed them whole apples, apple puree and apple juice (with the same amount of available carbohydrates and calories) in 3 separate morning studies, one week apart. We will use MRI to monitor the behaviour of the different meals in the gut and relate what we see to the gastrointestinal symptom scores.

Our aim is to investigate the gastrointestinal responses and satiety to different physical forms of the same apple test meal (containing FODMAPs) in Healthy Volunteers using MRI.

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professor-robin-spiller Professor Robin Spiller Robin's main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. He has twice edited the British Society of…
Shanthi Krishnasamy
dr-luca-marciani Dr Luca Marciani I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships…
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