Development of quantitative MRI measures for the preliminary assessment and characterization of the bowel wall in healthy volunteers with an intravenous Gadolinium-based contrast agent (ProHance) GerMivR Study

1st April 2015 - ongoing

Status: In Recruitment

Specialism: Imaging.

Team: Dr Rob ScottProfessor Guruprasad AithalDr Luca MarcianiDr Gordon MoranProfessor Robin Spiller.

Researchers from the Sir Peter Mansfield Imaging Centre (SPMIC) in collaboration with University College London and the NIHR Nottingham Digestive Diseases Biomedical Research unit (NDDBRU) have published non-invasive MRI techniques to measure small bowel and colonic motility as well as small bowel free water content. The Nottingham collaboration (NDDBRU and SPMIC) has also developed MRI techniques to reliably evaluate portal haemodynamic changes in blood flow associated with cirrhosis. MRI can also be used to monitor the changes in the bowel wall thickness, oedema and blood flow, for instance in relation to Crohn’s disease activity.

These MRI techniques will be further developed in this study and optimized to characterize the bowel wall in healthy volunteers. We will also investigate developing improved methods of studying bowel wall thickness, oedema, bowel wall blood flow and vessel permeability with increased sensitivity. Visualisation of the bowel is improved by the administration, orally and intravenously, of various contrast agents in clinical practice. We will scan healthy volunteers, to whom we will give both oral and intravenous contrast agents together with an akinetic agent (eg Buscopan) used for GI studies, on an ad hoc basis to enable this development of MRI techniques and evaluation process to continue. We would like to develop techniques to look at the blood flow within the bowel wall which will require administration of an intravenous Gadolinium-based contrast agent (eg ProHance 0.3mls/kg). We aim to recruit up to 20 healthy volunteers to this study.

People
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dr-rob-scott Dr Rob Scott
guruprasad-aithal Professor Guruprasad Aithal Professor Aithal has been a Consultant Hepatobiliary Physician at Nottingham University Hospitals NHS trust since 2001. He is the Head of the NIHR Nottingham Digestive Diseases Biomedical Research Centre, and the Head of Division for the Nottingham…
dr-luca-marciani Dr Luca Marciani I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships…
dr-gordon-moran Dr Gordon Moran Dr Moran did his undergraduate medical training at University of Malta Medical School and was awarded an MD in 1999. He completed his basic postgraduate training at St. Luke's Hospital in Malta and gained membership of the Royal College of Physicians of…
professor-robin-spiller Professor Robin Spiller Robin's main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. He has twice edited the British Society of…
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