Collection of biopsy, blood and stool samples from patients attending upper GI endoscopy to study the influence of host and bacterial factors on the outcome of Helicobacter infection (H Pylori)

1st December 2009 - ongoing

Status: Active

Specialism:

Team: Professor John Atherton.

The aim of this study is to collect biopsy tissue samples, blood and stool samples to be used in research. The samples collected will be used to understand the influence of host and bacterial factors on the outcome of Helicobacter pylori (H. pylori) infection. H. pylori are bacteria that live in the stomach of about a third of people in the UK. In most people H. pylori infection does not cause problems, however in a small proportion the infection causes stomach or duodenal ulcers or stomach cancer. Professor Atherton’s research group is studying factors which may explain why the infection leads to disease in some people but not others. There will be a variety of tests carried out on samples which includes histopathology to examine extent of disease, bacteria culture, analysis of strains and immune response. We hope to develop new non-invasive diagnostic tests that could change future H. pylori management. Patients who are scheduled to undergo an endoscopy will be approached to find out if they are interested in taking part in the study.

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