Characterisation of the structural changes associated with small bowel Permeability using MRI in Healthy volunteers (PerMinH)

1st March 2016 - ongoing

Status: In Recruitment

Specialism: Imaging, MR Imaging, Liver, Cirrhosis & Consequences.

Team: Professor Penny GowlandDr Rob ScottProfessor Penny GowlandDr Luca MarcianiProfessor Guruprasad AithalDr Caroline HoadDr Gordon MoranDr Rob Scott.

Funded by NIHR (2016 to 2017)

Nottingham Hospitals Charity (August 2015 – August 2016)

Researchers at the University of Nottingham have shown magnetic resonance imaging (MRI) can measure various changes in the bowel. Existing clinical MRI scans use swallowed substances to make the bowel more visible and injected medicine to stop the bowel moving. The development of a leaky bowel is an important event in several diseases such as inflammatory bowel disease (e.g. Crohn’s) and liver cirrhosis to predict those at risk of developing complications (e.g. infection). Very little is known about what changes happen to a bowel that makes it more leaky or where it occurs. There are no good or widely available ways to measure the leakiness of a patient’s bowel to guide who needs treatment nor how well it is working. This study will look at whether MRI can detect differences between a normal and leaky bowel in healthy volunteers by using a swallowed substance like aspirin to make the bowel temporarily more leaky. We hope to use this new set of MRI scans in future studies to look at changes in the bowel wall associated with disease (eg Crohn’s and liver cirrhosis).

Tests Involved

Patients taking part in the study will be invited to meet the research team at the Sir Peter Mansfield Imaging Centre three times:

  1. Screening visit - answer any questions, safety questionnaires and consent to the study
  2. Study visits 1
  3. Study Visit 2

Study visits will be two weeks apart. Each one will have:

  • Blood tests
  • Permeability test – have a drink and collect urine for two hours to measure how leaky the bowel is
  • MRI scan

If you are interested in taking part or want to find out more, please contact us with any questions or to request further information:

Call 0115 9514747 and ask for Lesley Martin quoting the “PerMinH study”, or email lesley.martin@nottingham.ac.uk

People
Photo Name Bio
professor-penny-gowland Professor Penny Gowland Developing quantitative MRI for biomedical applications. I am particularly interested in exploiting the capabilities of functional and anatomical ultra-high field MRI in neuroscience, in using the increased contrast to noise ratio available at ultrahigh…
dr-rob-scott Dr Rob Scott
dr-luca-marciani Dr Luca Marciani I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships…
guruprasad-aithal Professor Guruprasad Aithal Professor Aithal has been a Consultant Hepatobiliary Physician at Nottingham University Hospitals NHS trust since 2001. He is the Head of the NIHR Nottingham Digestive Diseases Biomedical Research Centre, and the Head of Division for the Nottingham…
caroline-hoad Dr Caroline Hoad
dr-gordon-moran Dr Gordon Moran Dr Moran did his undergraduate medical training at University of Malta Medical School and was awarded an MD in 1999. He completed his basic postgraduate training at St. Luke's Hospital in Malta and gained membership of the Royal College of Physicians of…
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