An investigation of the prevalence and dynamics of carriage of C. difficile in different IBD outpatient populations

1st January 2014 - ongoing

Status: Active

Specialism: Surgical.

Team: Dr Tanya Monaghan.

The aim of our study is to understand the mechanisms by which intestinal inflammation may occur in patients with bacterial infections (such as Clostridium difficile infection), ulcerative colitis and Crohn’s disease. The intestinal inflammation causes diarrhoea (sometimes with blood) and other symptoms such as abdominal pain. At present, we do not fully understand why or how inflammation occurs in these diseases. For this research, stool and blood samples from patients with bacterial infections, ulcerative colitis and Crohn’s disease will be studied. For comparative studies, we will also need to investigate stool and blood samples from patients who do not have these diseases. It is hoped that this research will allow a better understanding of the way in which inflammation occurs and may allow the future development of new drugs for these conditions, which are often difficult to treat.

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Dr Tanya Monaghan Dr Monaghan came to Nottingham in 2006 and took up the position as the first NIHR Academic Clinical Fellow in Gastroenterology. Alongside clinical training, she worked in the laboratory of Professor Yash Mahida. She was subsequently awarded a Wellcome…
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