A randomised controlled trial of the effect of the low FODMAP diet and dietary oligofructose on gastrointestinal form, function and microbiota in healthy volunteers (FOG)

1st September 2014

Status: Ended

Specialism: Lower GI.

Team: Professor Robin Spiller.

The purpose of the study is to investigate the effect of changing the amount of poorly digested, fermentable carbohydrate in the diet of healthy volunteers on MRI parameters of GI physiology such as colonic volume and whole gut transit time.

In addition we will collect samples for analysis of faecal microbiota, faecal short-chain fatty acid concentration and urinary metabolites. This combined approach will allow associations to be made between changes in di, microbiota and physiology.

As well as testing hypotheses on the relationship between diet and physiology this study will act as a pilot for such a combined approach, providing valuable data for future programme grants.

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