A pilot double blind, randomised, placebo controlled trial of the effect of a diet low in poorly digested carbohydrates on symptoms of post-infective bowel dysfunction (CEDRIC)

1st August 2014

Status: Ended

Specialism: Lower GI.

Team: Professor Robin SpillerDr Giles Major.

Up to 1 in 4 people report that their bowel habit remains disturbed 3 months after suffering a bowel infection with the germ Campylobacter. This may be because the infection disturbs the microbiota, the bacteria that usually live inside the bowel and are important for bowel function and general health. A major task of the gut bacteria is to deal with food that is not properly digested higher up the intestine, and the type of diet eaten will also affect the kind of bacteria that live in the lower bowel (colon).

The ‘low FODMAP’ diet restricts the amount of poorly digested sugar that is eaten. It is sometimes used by people with symptoms such as discomfort and bloating when they are diagnosed as Irritable Bowel Syndrome. This study will investigate whether following the low FODMAP diet improves symptoms in people with bowel disturbance after Campylobacter and other bowel infections, and what effects it may have on the bacteria in the colon.

Participants will be recruited from a preceding study (called CERAMIC) in Nottingham where they have been followed up since their Campylobacter infection. WE also plan to recruit people diagnosed with post-infectious irritable bowel syndrome through Prof Spiller’s clinics and research studies. Participants will receive dietary advice and be assessed by questionnaires and MRI scans. They will also provide stool samples for analysis of the bacteria. The study is expected to last up to 3 years.

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professor-robin-spiller Professor Robin Spiller Robin's main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. He has twice edited the British Society of…
dr-giles-major Dr Giles Major I am interested in the interaction between diet, the gut microbiota and intestinal physiology, and how these interactions affect digestive symptoms and disease. I am part of the University of Nottingham GI MRI research group. We use novel magnetic…
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