A new MRI-based disease measure in Ulcerative Colitis – Optimisation studies in Healthy Volunteers (MRinUCHV)
1st January 2018 - ongoing
Status: In Recruitment
Specialism: Imaging, MR Imaging, Lower GI.
Ulcerative colitis (UC) is an inflammatory condition of the large bowel. Currently an endoscopy is the best way to assess a patient’s response to treatment. This is invasive, requires bowel preparation and can sometimes feel uncomfortable or lead to serious complications. One alternative to measure the amount of inflammation is to use Magnetic Resonance Imaging (MRI). However, new MRI disease activity measures are needed before this can happen. This study will allow us to test new imaging techniques initially on healthy volunteers and then in future studies on UC patients with the aim to provide more effective, less invasive tests for the future.
To carry out these measurements on the colon wall, subjects need to ingest 1 Litre of bowel preparation (2.5% w/w mannitol and 0.2 % locust bean gum powder dissolved in water). This is consumed over a 60-90 minute time period prior to scanning. This solution distends the bowel allowing the bowel wall to become more easily identifiable on the MR images, however induces significant motion of the bowel wall. An injection of an anti-spasmodic agent (Buscopan) reduces the motion of the bowel wall to allow the position of the wall segments to remain consistent when images are being acquired.
New emerging Quantitative MRI sequences of Diffusion, and T2 relaxation will be optimised for the colon, along with measurements of colonic motility (acquired prior to administration of the anti-spasmodic agent).
|Dr Gordon Moran||Dr Moran did his undergraduate medical training at University of Malta Medical School and was awarded an MD in 1999. He completed his basic postgraduate training at St. Luke's Hospital in Malta and gained membership of the Royal College of Physicians of…|
|Dr Caroline Hoad|
|Professor Penny Gowland||Developing quantitative MRI for biomedical applications. I am particularly interested in exploiting the capabilities of functional and anatomical ultra-high field MRI in neuroscience, in using the increased contrast to noise ratio available at ultrahigh…|