MODS Study

What is the purpose of this study?

The study is aimed at helping us better understand how bisacodyl works in the body. Bisacodyl is a common laxative to treat constipation. We can tell a lot from looking at your bowels using magnetic resonance imaging (MRI). This study compares images of your bowels when you take 5 mg bisacodyl or a placebo (dummy pill).

What does it involve?

You would be in this study for about 2-3 months.

It requires 9 visits: 1 for screening to determine if you are eligible to take part, and then two arms of the study each requiring 4 visits. Each arm consists of confirmation of eligibility, a full MRI study day and 2 short MRI study days, see diagram below. There will be a gap between the two parts of approximately 2 weeks (called the “wash-out period”) to allow any effect of treatment to wear off while you will continue your normal activities.

Overall you will be having a total of 18 MRI scans. These do not harm you but if you have specific metal in your body you may not be able to have MRI scans. We also ask you to keep a stool diary throughout the study and give us a total of six stool samples. During the long study days we will also give you a standardised meal: rice pudding with raspberry jam and bran with some orange juice.

For more information and how you can participate please contact Lesley Martin by email: or by phone: 0115 95 14747 please mention the study name: MODS


Professor Robin Spiller

Dr Maura Corsetti

Dr Luca Marciani

Professor Penny Gowland

Dr Neele Dellschaft

Dr Hannah Williams