Endoscopic Imaging & Translational Endoscopy

The endoscopy research team led by Professor Ragunath was established in 2004. Since then, we have produced over 100 original articles through successful and long term national and international collaborations with centres of excellence including Cambridge, London, Amsterdam, and Mayo Clinic USA. Our research has a strong translational potential and resulted in several changes in clinical endoscopy practice both within our hospital and globally. Our Endoscopy unit in Nottingham is now a recognised European training centre of excellence attracting fellows and researchers from all over the world.

Our research theme is focused on the evaluating the role of novel imaging technologies and endoscopic techniques in:

  • The detection and in-vivo characterisation of several autoimmune, inflammatory, and pre-malignant gastrointestinal (GI) mucosal diseases including H. Pylori, atrophic gastritis, coeliac disease, gastroesophageal reflux disease, early neoplasia in patients with inflammatory bowel disease and Barrett’s oesophagus, early gastric cancer, and colonic polyps.
  • The staging and treatment of several GI disorders including early GI cancer, colonic neoplasia, and acute GI bleeding.

The aims of our research are to:

  1. Explore non-invasive screening tools.
  2. Establish methods for real time diagnosis and early detection.
  3. Evaluate the efficacy of minimally invasive as well as novel endoscopic therapies in the GI tract.

Current projects:

Diagnostics

Novel endoscopic imaging techniques

Lead: Prof. Ragunath

Expertise in evaluation of novel imaging and technologies in the GI tract as well as prototype evaluation. We have established track record in industry collaboration and examples are: auto fluorescence imaging (Olympus), narrow band imaging (Olympus), iScan (Pentax), high definition endoscopy (Pentax), confocal laser endomicroscopy (Mauna Kea), dual focus endoscopy (Olympus).

Devices

Testing diagnostic accuracy and therapeutic interventions of new endoscopic devices

Lead: Prof. Ragunath

Expertise in evaluation of novel endoscopic and non-endoscopic devices in the GI tract.

Examples include:

  1. Multicentre feasibility study (BRU and NIHR adopted) evaluating the diagnostic accuracy of a novel (CE marked) portable transnasal endoscope (EGScanTM) device for the detection of Barrett’s oesophagus and oesophageal varices in the outpatient clinic. In collaboration with the manufacturer Intromedic Ltd, Seoul, South Korea who provided grant support and equipment loan.
  2. Multicentre evaluation of a new generation prototype capsule endoscopy system to enhance reading times in the small bowel (Olympus).
  3. The utility of and participation in a multicentre trial evaluating a novel minimally invasive cell sampling device (the ‘Cytosponge-TFF3 test’) that can be used to identify patients with reflux symptoms who warrant endoscopy to diagnose Barrett’s esophagus.
  4. Multicentre study evaluating the Halo RFA in Barretts oesophagus (Covidien)
  5. Mulicentre study evaluating a novel EUS guided tissue acquisition needle (Cook Medical)

Potential for collaborative projects:

As detailed above, collaborative research projects has formed the main core of our work, so we aim to continue to build and expand our network of collaborations

Key team members (PIs):

Professor Krish Ragunath

Dr. Sarmed S. Sami

Administrative contact:

BRU Reception

Tel: +44 (0) 115 9709966

Email: NDDCBRU@nottingham.ac.uk