About Us

About the Nottingham Digestive Diseases Biomedical Research Centre

The NIHR Nottingham Digestive Diseases Biomedical Research Centre (NDDBRC) was established in 2008 from a successful NIHR infrastructure grant award. Initial funding supported the building of the research facility including the area to involve and evaluate volunteers and patients safely, laboratory, employment of researchers and support staff as well as the key equipment. Successful renewal of NDDBRU provided us funds to support experimental medicine studies within the area of our focus on ‘Infection, inflammation and consequences within the GI tract and liver’.

NIHR NDDBRC has become the central hub to the gastroenterology and hepatology research within the partnership of University of Nottingham and Nottingham University Trust, bringing together 67 principal investigators bridging basic scientific and clinical fields. Among this large group, we have expertise in a wide range of areas, techniques and methodologies although we focus on early translational studies including pre-clinical and phase I/II studies. We host large deeply phenotyped cohort of patients, linked databases and biological samples. Our academic partnership extends to industry links and we do have experience in developing and evaluating, drugs, devices and health care interventions.

NIHR NDDBRC has a mission to take the most promising basic biomedical research breakthroughs and translate them into patient benefit. We focus on developing novel tests, techniques as well as new treatments. We perform experimental medicine investigations into mechanisms underlying disease processes using biological samples from people; we evaluate the efficacy of interventions in volunteers and patients.

Our research focus is on ’The infections, inflammation and consequences in the GI tract and liver’.

You can find out about our specific areas here

As well as Clinical Researchers in the School of Medicine, the membership of the BRC includes some of the best researchers in the nationally first-rated Sir Peter Mansfield MRI Imaging Centre and many Microbiologists and Virologists from the School of Molecular Medicine and The School of Life Sciences.

The NDDBRC aims to provide

  • A central facility for patient based translational research.
  • Staff dedicated to patient based translational research.
  • As well as research leaders, the BRC specifically funds a cadre of skilled Research Nurses, Research Technicians dealing with tissue and blood samples, Administrative and Secretarial Staff, Clinical Trials Experts, Research Facilitators and a Database Manager.
  • Registers of volunteer patients with specific diseases and collections of blood, tissue and pathogens for translational research.

For latest updates on our research and for information on other NIHR Nottingham Biomedical Research Centre (BRC) themes: https://nottinghambrc.nihr.ac.uk/